Bio::Tools::Phylo::PAML::ModelResult.3pm

Langue: en

Version: 2010-05-19 (ubuntu - 24/10/10)

Section: 3 (Bibliothèques de fonctions)

NAME

Bio::Tools::Phylo::PAML::ModelResult - A container for NSSite Model Result from PAML

SYNOPSIS

   # get a ModelResult from a PAML::Result object
   use Bio::Tools::Phylo::PAML;
   my $paml = Bio::Tools::Phylo::PAML->new(-file => 'mlc');
   my $result = $paml->next_result;
   foreach my $model ( $result->get_NSSite_results ) {
     print $model->model_num, " ", $model->model_description, "\n";
     print $model->kappa, "\n";
     print $model->run_time, "\n";
 # if you are using PAML < 3.15 then only one place for POS sites
    for my $sites ( $model->get_pos_selected_sites ) {
     print join("\t",@$sites),"\n";
    }
 # otherwise query NEB and BEB slots
    for my $sites ( $model->get_NEB_pos_selected_sites ) {
      print join("\t",@$sites),"\n";
    }
 
    for my $sites ( $model->get_BEB_pos_selected_sites ) {
     print join("\t",@$sites),"\n";
    }
 
   }
 
 

DESCRIPTION

Describe the object here

FEEDBACK

Mailing Lists

User feedback is an integral part of the evolution of this and other Bioperl modules. Send your comments and suggestions preferably to the Bioperl mailing list. Your participation is much appreciated.
   bioperl-l@bioperl.org                  - General discussion
   http://bioperl.org/wiki/Mailing_lists  - About the mailing lists
 
 

Support

Please direct usage questions or support issues to the mailing list:

bioperl-l@bioperl.org

rather than to the module maintainer directly. Many experienced and reponsive experts will be able look at the problem and quickly address it. Please include a thorough description of the problem with code and data examples if at all possible.

Reporting Bugs

Report bugs to the Bioperl bug tracking system to help us keep track of the bugs and their resolution. Bug reports can be submitted via email or the web:
   http://bugzilla.open-bio.org/
 
 

AUTHOR - Jason Stajich

Email jason@open-bio.org

APPENDIX

The rest of the documentation details each of the object methods. Internal methods are usually preceded with a _

new

  Title   : new
  Usage   : my $obj = Bio::Tools::Phylo::PAML::ModelResult->new();
  Function: Builds  a new Bio::Tools::Phylo::PAML::ModelResult object 
  Returns : an instance of Bio::Tools::Phylo::PAML::ModelResult
  Args    : -model_num           => model number
            -model_description   => model description
            -kappa               => value of kappa
            -time_used           => amount of time
            -pos_sites           => arrayref of sites under positive selection
            -neb_sites           => arrayref of sites under positive selection (by NEB analysis)
            -beb_sites           => arrayref of sites under positive selection (by BEB analysis)
            -trees               => arrayref of tree(s) data for this model
            -shape_params        => hashref of parameters 
                                    ('shape' => 'alpha',
                                     'gamma' => $g, 
                                     'r' => $r, 
                                     'f' => $f 
                                     )
                                     OR
                                     ( 'shape' => 'beta',
                                       'p' => $p, 
                                       'q' => $q
                                      )
            -likelihood          => likelihood
            -num_site_classes    => number of site classes
            -dnds_site_classes   => hashref with two keys, 'p' and 'w'
                                    which each point to an array, each
                                    slot is for a different site class.
                                    'w' is for dN/dS and 'p' is probability
 
 

model_num

  Title   : model_num
  Usage   : $obj->model_num($newval)
  Function: Get/Set the Model number (0,1,2,3...)
  Returns : value of model_num (a scalar)
  Args    : on set, new value (a scalar or undef, optional)
 
 

model_description

  Title   : model_description
  Usage   : $obj->model_description($newval)
  Function: Get/Set the model description
            This is something like 'one-ratio', 'neutral', 'selection'
  Returns : value of description (a scalar)
  Args    : on set, new value (a scalar or undef, optional)
 
 

time_used

  Title   : time_used
  Usage   : $obj->time_used($newval)
  Function: Get/Set the time it took to run this analysis
  Returns : value of time_used (a scalar)
  Args    : on set, new value (a scalar or undef, optional)
 
 

kappa

  Title   : kappa
  Usage   : $obj->kappa($newval)
  Function: Get/Set kappa (ts/tv)
  Returns : value of kappa (a scalar)
  Args    : on set, new value (a scalar or undef, optional)
 
 

num_site_classes

  Title   : num_site_classes
  Usage   : $obj->num_site_classes($newval)
  Function: Get/Set the number of site classes for this model
  Returns : value of num_site_classes (a scalar)
  Args    : on set, new value (a scalar or undef, optional)
 
 

dnds_site_classes

  Title   : dnds_site_classes
  Usage   : $obj->dnds_site_classes($newval)
  Function: Get/Set dN/dS site classes, a hashref
            with 2 keys, 'p' and 'w' which point to arrays
            one slot for each site class.
  Returns : value of dnds_site_classes (a hashref)
  Args    : on set, new value (a scalar or undef, optional)
 
 

get_pos_selected_sites

  Title   : get_pos_selected_sites
  Usage   : my @sites = $modelresult->get_pos_selected_sites();
  Function: Get the sites which PAML has identified as under positive
            selection (w > 1).  This returns an array with each slot
            being a site, 4 values, 
            site location (in the original alignment)
            Amino acid    (I *think* in the first sequence)
            P             (P value)
            Significance  (** indicated > 99%, * indicates >=95%)
  Returns : Array
  Args    : none
 
 

add_pos_selected_site

  Title   : add_pos_selected_site
  Usage   : $result->add_pos_selected_site($site,$aa,$pvalue,$signif);
  Function: Add a site to the list of positively selected sites
  Returns : count of the number of sites stored
  Args    : $site   - site number (in the alignment)
            $aa     - amino acid under selection 
            $pvalue - float from 0->1 represent probability site is under selection according to this model
            $signif - significance (coded as either empty, '*', or '**'
 
 

get_NEB_pos_selected_sites

  Title   : get_NEB_pos_selected_sites
  Usage   : my @sites = $modelresult->get_NEB_pos_selected_sites();
  Function: Get the sites which PAML has identified as under positive
            selection (w > 1) using Naive Empirical Bayes.  
            This returns an array with each slot being a site, 4 values, 
            site location (in the original alignment)
            Amino acid    (I *think* in the first sequence)
            P             (P value)
            Significance  (** indicated > 99%, * indicates > 95%)
            post mean for w
  Returns : Array
  Args    : none
 
 

add_NEB_pos_selected_site

  Title   : add_NEB_pos_selected_site
  Usage   : $result->add_NEB_pos_selected_site($site,$aa,$pvalue,$signif);
  Function: Add a site to the list of positively selected sites
  Returns : count of the number of sites stored
  Args    : $site   - site number (in the alignment)
            $aa     - amino acid under selection 
            $pvalue - float from 0->1 represent probability site is under selection according to this model
            $signif - significance (coded as either empty, '*', or '**'
            $postmean - post mean for w
 
 

get_BEB_pos_selected_sites

  Title   : get_BEB_pos_selected_sites
  Usage   : my @sites = $modelresult->get_BEB_pos_selected_sites();
  Function: Get the sites which PAML has identified as under positive
            selection (w > 1) using Bayes Empirical Bayes.  
            This returns an array with each slot being a site, 6 values, 
            site location (in the original alignment)
            Amino acid    (I *think* in the first sequence)
            P             (P value)
            Significance  (** indicated > 99%, * indicates > 95%)
            post mean for w (mean)
            Standard Error for w (SE)
  Returns : Array
  Args    : none
 
 

add_BEB_pos_selected_site

  Title   : add_BEB_pos_selected_site
  Usage   : $result->add_BEB_pos_selected_site($site,$aa,$pvalue,$signif);
  Function: Add a site to the list of positively selected sites
  Returns : count of the number of sites stored
  Args    : $site   - site number (in the alignment)
            $aa     - amino acid under selection 
            $pvalue - float from 0->1 represent probability site is under selection according to this model
            $signif - significance (coded as either empty, '*', or '**'
            $postmean - post mean for w
            $SE       - Standard Error for w
 
 

next_tree

  Title   : next_tree
  Usage   : my $tree = $factory->next_tree;
  Function: Get the next tree from the factory
  Returns : L<Bio::Tree::TreeI>
  Args    : none
 
 

get_trees

  Title   : get_trees
  Usage   : my @trees = $result->get_trees;
  Function: Get all the parsed trees as an array
  Returns : Array of trees
  Args    : none
 
 

rewind_tree_iterator

  Title   : rewind_tree_iterator
  Usage   : $result->rewind_tree_iterator()
  Function: Rewinds the tree iterator so that next_tree can be 
            called again from the beginning
  Returns : none
  Args    : none
 
 

add_tree

  Title   : add_tree
  Usage   : $result->add_tree($tree);
  Function: Adds a tree 
  Returns : integer which is the number of trees stored
  Args    : L<Bio::Tree::TreeI>
 
 

shape_params

  Title   : shape_params
  Usage   : $obj->shape_params($newval)
  Function: Get/Set shape params for the distribution, 'alpha', 'beta'
            which is a hashref 
            with 1 keys, 'p' and 'q' 
  Returns : value of shape_params (a scalar)
  Args    : on set, new value (a scalar or undef, optional)
 
 

likelihood

  Title   : likelihood
  Usage   : $obj->likelihood($newval)
  Function: log likelihood
  Returns : value of likelihood (a scalar)
  Args    : on set, new value (a scalar or undef, optional)